What is ALOIS?
ALOIS was created and is maintained by the Cochrane Dementia and Cognitive Improvement Group. Uniquely, ALOIS is study-based: multiple references to the same trial are grouped together. ALOIS covers all randomised controlled trials of interventions:

  • for people with dementia
  • for people with cognitive impairment
  • for the improvement of, or prevention of decline in, cognitive function in healthy people

It was created in 2008 thanks to a grant from the Alzheimer's Association. It is a free open-access resource, available to anyone with an internet connection.

What is on ALOIS?
The register mainly contains records of RCTs (Randomized Controlled Trials) though there are also some CCTs (Controlled Clinical Trials) and some Open-label studies. For definitions of these study designs, see the Glossary

There are currently around 5500 studies on ALOIS (November 2018). We are working hard to make ALOIS as comprehensive as possible.

Who is ALOIS for? 
ALOIS is for anyone interested in trials being conducted in the area of dementia and cognitve improvement. However, we see our main potential users being:

  • Authors of systematic reviews (Cochrane and others)
  • Funders who want to know what research already exists (and where there are potential research gaps)
  • Researchers identifying gaps in the research and writing grant applications
  • Teachers of evidence-based dementia care
  • Students of evidence-based dementia care
  • Carers and clinicians who want easy and quick access to the evidence in this area

ALOIS aims to take away some of the most frustrating elements of trying to find trials in this area. It hopes to provide a platform that facilitates the critical assessment of trials and to encourage all parties interested in evidenced-based medicine in this subject to contribute their knowledge of studies to this EBM community resource.

How is ALOIS maintained?
This site is looked after by the Cochrane Dementia and Cognitive Improvement Group (CDCIG). This group is responsible for creating the search strategies to retrieve relevant reports of studies, running the searches, assessing the results and coding and uploading the study details onto the register. 
What sources are searched and how often are they searched?
The following databases are searched monthly:

  • Medline (Ovid SP)
  • Embase (Ovid SP)
  • PsycInfo (Ovid SP)
  • Cinahl (EBSCOhost)
  • Lilacs (Bireme)

The following trials registers are searched monthly:

  • ClinicalTrials.gov: https://clinicaltrials.gov 
  • WHO Portal (covers ClinicalTrials.gov; ISRCTN; Australian and New Zealand Clincal Trial Registry; Chinese Clinical Trial Register; India Clinical Trials Registry; German Clinical trials Register; Iranian Registry of Clinical Trials; Sri Lanka Clinical Trials Registry; The Netherlands National trial Register): www.who.int/trialsearch   

Page last updated: 10 November 2018