Enette 2020

Current Status of Trial
Study Aim
Treatment Dementia
Study Design
Intervention type
Aerobic training
Dosage and Duration
52 participants were randomly allocated into three groups (CAT n = 14; IAT n = 17; and Controls n = 21). CAT and IAT consisted of 18 sessions of 30-min cycling, twice a week, over 9 weeks. During the same period, controls were engaged in interactive information sessions.
Absolute Number of Participants
Health Status/Diagnosis
Alzheimer Disease (AD)
Primary outcomes
Brain derived neurotrophic factor (BDNF) plasma level // Aerobic fitness // Cognitive performance // Quality of life
Key Points
"No significant change was measured in terms of plasma BDNF level and cognitive performance after interventions, in all groups compared to baseline. After 9 weeks, CAT and IAT significantly improved aerobic fitness parameters compared to controls (METs: + 0.6 and + 1.0 vs. + 0.4; MTP: + 16 watts and + 20 watts vs. + 10 watts; and functional capacities (6MWT: + 22 m and + 31 m vs. -40 m). Compared to controls, QoL-AD after CAT was improved (+ 2 points; p = 0.02). Conclusions Neither aerobic exercise modalities significantly modified plasma BDNF levels and cognitive performances. CAT and IAT enhanced aerobic fitness and functional capacities in AD patients and CAT their QoL." Enette 2020