Huang 2021

Current Status of Trial
Completed
Study Aim
Treatment MCI
Study Design
RCT
Blinding
Single-blind
Intervention type
Non-pharmacological
Intervention
Aerobic training // Resistance training
Dosage and Duration
Participants in the intervention groups underwent a group training program and self-paced home training for 26 weeks. The control group received lectures about health promotion.
Absolute Number of Participants
415
Health Status/Diagnosis
Mild Cognitive Impairment (MCI) // Subjective Cognitive Impairment
Co-morbid Health Condition/Other Participant Characteristics
Aged 65–85 years old
Country or Countries of Recruitment
Japan
Unit of Allocation and/or Setting
Community setting
Primary outcomes
Locomotion // Cognition // Psychological function
Key Points
"Between-group differences were exhibited with Z-score change in individual domain and combination of all domains. At baseline, mean age of all participants (47% women) was 72.3 ± 4.6 years, with a mean composited IC Z-score of −0.2 ± 0.5. Overall, AT and RT improved composite IC Z-scores by 0.17 (95% confidence interval [CI] 0.03–0.30) and 0.17 (95% CI 0.05–0.28) at week 26, respectively, but the beneficial effects waned at week 52. No significant differences in composite IC Z-scores were found in the AT+RT group at weeks 26 and 52. Twenty-six-week AT with self-paced home training and RT with self-paced home training improve IC among community-dwelling older adults with subjective memory concerns, but the benefits waned subsequently." Huang 2021