Jiang 2021

Current Status of Trial
Completed
Study Aim
Cognitive Enhancement (healthy)
Study Design
RCT
Blinding
Unclear
Intervention type
Non-pharmacological
Intervention
Cognitive training
Dosage and Duration
32 community-dwelling older adults, 18 were randomly assigned to the training group to receive 24 sessions of multi-domain cognitive training (MDCT) over 12 weeks, and 14 to the control group.
Absolute Number of Participants
32
Health Status/Diagnosis
Healthy Elderly
Unit of Allocation and/or Setting
Community setting
Primary outcomes
Cognition
Key Points
"Compared with controls, participants received MDCT achieved significant larger gain in terms of delayed memory with a trend of better global cognitive function. In addition, Sigma coefficient of small-worldness were reduced in the MDCT group relative to the control group. Correlation between changes in Sigma and in delayed memory index were found among controls, however, not among older adults received MDCT. Our results demonstrated the modulating effects of cognitive training on the small-world architecture of brain structural network. And the present study suggested a trade-off mechanism underlying the benefits of cognitive training among aged people, where brain sacrificed its cost-effectiveness of network wiring for better cognitive functions" Jiang 2021