Kim 2021

Current Status of Trial
Study Aim
Cognitive Enhancement (healthy)
Study Design
Intervention type
Probiotic supplementation // Placebo
Dosage and Duration
Sixty-three healthy elders (>= 65 years) consumed either placebo or probiotics containing Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI for 12 weeks.
Absolute Number of Participants
Health Status/Diagnosis
Healthy elderly
Co-morbid Health Condition/Other Participant Characteristics
Aged 65 years or older
Unit of Allocation and/or Setting
Community setting
Key Points
"Blood brain-derived neurotrophic factor (BDNF) was determined using enzyme-linked immunosorbent assay. Relative abundance of inflammation-causing gut bacteria was significantly reduced at Week 12 in the probiotics group (p < .05). The probiotics group showed greater improvement in mental flexibility test and stress score than the placebo group (p < .05). Contrary to placebo, probiotics significantly increased serum BDNF level (p < .05). Notably, the gut microbes significantly shifted by probiotics (Eubacterium and Clostridiales) showed significant negative correlation with serum BDNF level only in the probiotics group (R-S = -0.37, R-S = -0.39, p < .05)." Kim 2021