Study ID(s) and Acronym(s)
NCT03913637 / ForAging
Current Status of Trial
Study Aim
Treatment MCI
Study Design
Intervention type
Strategy training
Dosage and Duration
Occupational therapists deliver Strategy Training in older adults' homes to enhance real-world application. Strategy training optimizes engagement in meaningful daily activities through generating self-selected goals, monitoring daily activities, scheduling activities, and problem-solving solutions to barriers experienced when engaging in activities.
Absolute Number of Participants
Health Status/Diagnosis
Mild Cognitive Impairment (MCI)
Study completion date
Estimated primary completion: June 1, 2023
Primary outcomes
Change in disability
Key Points
This trial will test the effect of Strategy Training compared to Enhanced Usual Care on change in disability among older adults with Mild Cognitive Impairment (MCI) and assess the extent to which Central Nervous System amyloid-beta deposition and neurocognitive function modify the relationship between Strategy Training and Enhanced Usual Care on change in disability. Assessments will be obtained at Baseline, 6 week short assessment, 6 and 12 months post intervention. Interventions, such as Strategy Training, focused on slowing emergence of disability despite underlying pathology may keep older adults as engaged in meaningful daily activities for as long as possible. This project tests a novel and promising non-pharmacological intervention and will inform our understanding of important effect modifiers- amyloid beta deposition and executive function- on change in performance of cognitively challenging daily activities. Enhancing our understanding of amyloid beta deposition, executive function, disability, and a promising non-pharmacological intervention could support aging for millions of older adults who, in the near future, will experience disability related to MCI.