Shi 2019

Study ID(s) and Acronym(s)
17014122/ChiCTR
Current Status of Trial
Completed
Study Aim
Other
Study Design
RCT
Blinding
Double-blind
Intervention type
Pharmacological
Intervention
Dexmedetomidine // propofol
Dosage and Duration
One hundred and sixty-four patients were enrolled after cardiac surgery between June 2009 and December 2016. Patients were assigned by a computer-generated randomization sequence in a 1:1 ratio to receive dexmedetomidine general anesthesia maintenance or propofol general anesthesia maintenance. POD was assessed every day with confusion assessment method for intensive care units (ICU) during the first 5 postoperative days
Absolute Number of Participants
164
Health Status/Diagnosis
Post-operative delirium (POD)
Unit of Allocation and/or Setting
Hospital setting
Primary outcomes
Delirium
Key Points
"There was no significance in incidence of POD between the dexmedetomidine group and the propofol group (P=0.0758). In patients treated with dexmedetomidine, the median onset time of delirium was delayed (second day vs first day) and the duration of delirium reduced (2 days vs 3 days) when compared with propofol-treated patients. The dexmedetomidine-treated patients also displayed a lower VAS score and less opiate analgesic consumption. No difference was observed in respect to other postoperative outcomes" Shi 2019