Tonga 2021

Current Status of Trial
Study Aim
Treatment MCI
Study Design
Intervention type
Multicomponent psychotherapy
Dosage and Duration
he intervention group (n = 100) received 11 individual weekly sessions of the CORDIAL program. This intervention includes elements from CBT, cognitive rehabilitation, and reminiscence therapy. The control group (n = 98) received treatment-as-usual.
Absolute Number of Participants
Health Status/Diagnosis
Mild Cognitive Impairment (MCI) // Mild Dementia
Primary outcomes
Montgomery-Asberg Depression Rating Scale (MADRS)
Key Points
"A linear mixed model demonstrated that the depressive symptoms assessed by MADRS were significantly more reduced in the intervention groups as compared to the control group (p < 0.001). The effect persisted for 6 months after the intervention. No significant differences between groups were found in neuropsychiatric symptoms or quality of life." Tonga 2021