Whyte 2021

Current Status of Trial
Completed
Study Aim
Cognitive Enhancement (healthy)
Study Design
RCT
Blinding
Double-blind
Intervention type
Pharmacological
Intervention
Wild blueberry // Placebo
Dosage and Duration
Participants consumed a breakfast meal and 1-cup equivalent WBB drink or matched placebo beverage on two occasions.
Absolute Number of Participants
35
Health Status/Diagnosis
Middle-aged adults
Co-morbid Health Condition/Other Participant Characteristics
Aged 40–65 years old
Primary outcomes
Metabolic function // Cognition
Key Points
"analysis of the memory-related Auditory Verbal Learning Task (AVLT) word recognition measure revealed a decrease in performance over the test day after placebo intake, whereas performance after WBB was maintained. For the AVLT word rejection measure, participants identified more foils following WBB in comparison to placebo. Benefits were also observed for EF on the Go/No-Go task with fewer errors following WBB intake on cognitively demanding invalid No-Go trials in comparison to placebo. Furthermore, in comparison to placebo, response times were faster for the Go/No-Go task, specifically at 4 h and 8 h following WBB treatment. We also observed reduced post-meal glucose and insulin, but not triglyceride, concentrations in comparison to placebo over the first 2 h following ingestion. Though the addition of Age, BMI, glucose and insulin as covariates to the analysis reduced the significant effect of beverage for AVLT word rejection, metabolic outcomes did not interact with treatment to predict cognitive performance with the exception of one isolated trend." Whyte 2021